---
scientific_name: Glycine max
gene_symbols:
  - GmSPX5
gene_symbol_long: SYG1/Pho81/Xpr1 5
gene_model_pub_name: Glyma10g40820
gene_model_full_id: glyma.Wm82.gnm1.ann1.Glyma10g40820
confidence: 5
curators:
  - Marlene Dorneich-Hayes
comments:
  - SPX5 is most strongly expressed in nodules.
  - Phosphate deficiency promotes expression of SPX5 in nodules but decreases SPX5 expression in roots. Nitrogen deficiency decreased SPX5 expression in roots.
  - SPX5 is upregulated by arbuscular mycorrhizal fungal infection in phosphate-deficient conditions.
  - SPX5 promotes binding of NF-YC4 to the promoter of ASL6, increasing expression of ASL6 during nodule development.
phenotype_synopsis: SPX5 upregulates ASL genes to positively regulate nodule number. Unlike other SPX genes, SPX5 does not affect expression of PHR genes.
traits:
  - entity_name: regulation of biological process involved in symbiotic interaction
    entity: GO:0043903
  - entity_name: nodulation
    entity: GO:0009877
  - relation_name: positively regulates
    relation: RO:0002213
references:
  - citation: Zhuang, Xue et. al., 2021
    doi: 10.1111/tpj.15520
    pmid: 34587329
  - citation: Yao, Tian et. al., 2014
    doi: 10.1093/aob/mcu147
    pmid: 25074550
  - citation: Yang, Lan et. al., 2022
    doi: 10.1111/jipb.13207
    pmid: 34962095
---
scientific_name: Glycine max
gene_symbols:
  - GmNF-YC4
gene_symbol_long: Nuclear Factor Y subunit C4
gene_model_pub_name: Glyma06g17780
gene_model_full_id: glyma.Wm82.gnm1.ann1.Glyma06g17780
confidence: 4
curators:
  - Marlene Dorneich-Hayes
comments:
  - NF-YC4 positively regulates nodule number and nitrogenase activity.
  - SPX5 promotes binding of NF-YC4 to the promoter of ASL6, increasing expression of ASL6 during nodule development.
phenotype_synopsis: NF-YC4 is a transcription factor which upregulates ASL genes to positively regulate nodule number.
traits:
  - entity_name: DNA-binding transcription factor activity
    entity: GO:0003700
  - entity_name: regulation of biological process involved in symbiotic interaction
    entity: GO:0043903
  - entity_name: nodulation
    entity: GO:0009877
  - relation_name: positively regulates
    relation: RO:0002213
references:
  - citation: Zhuang, Xue et. al., 2021
    doi: 10.1111/tpj.15520
    pmid: 34587329
  - citation: Yang, Lan et. al., 2022
    doi: 10.1111/jipb.13207
    pmid: 34962095