---
scientific_name: Glycine max
gene_symbols:
  - GmNNC1
gene_symbol_long: Nodule Number Control 1
gene_model_pub_name: Glyma12g07800
gene_model_full_id: glyma.Wm82.gnm2.ann1.Glyma.12G078000
confidence: 5
curators:
  - Marlene Dorneich-Hayes
comments:
  - Expression patterns of NNC1 were studied with GAL4/UAS, GUS, and GFP reporter systems.
  - Its function was confirmed with RNAi knockdown and transgenic overexpression studies.
  - The activity of NNC1 is modulated by miR172c to fine-tune nodulation and symbiosis.
  - miR172c cleaves the protein product of NNC1, allowing ENOD40 to be transcribed.
  - miR172c is, in turn, negatively regulated by NARK (see Searle, Men et. al., 2003).
phenotype_synopsis: NNC1 is a transcription factor that negatively regulates nodule number by repressing GmENOD40.
traits:
  - entity_name: DNA-binding transcription factor activity
    entity: GO:0003700
  - entity_name: regulation of biological process involved in symbiotic interaction
    entity: GO:0043903
  - entity_name: nodulation
    entity: GO:0009877
  - relation_name: negatively regulates
    relation: RO:0002212
references:
  - citation: Wang, Wang et. al., 2014
    doi: 10.1105/tpc.114.131607
    pmid: 25549672
  - citation: Searle, Men et. al., 2003
    doi: 10.1126/science.1077937
    pmid: 12411574
  - citation: Yang, Lan et. al., 2022
    doi: 10.1111/jipb.13207
    pmid: 34962095