---
scientific_name: Glycine max
gene_symbols:
  - GmDRR1
gene_symbol_long: Disease Resistance Responsive 1
gene_model_pub_name: Glyma.11G150400
gene_model_full_id: glyma.Wm82.gnm2.ann1.Glyma.11G150400
confidence: 3
curators:
  - Marlene Dorneich-Hayes
  - Scott Kalberer
comments:
  - The importance of GmDRR1 in nodule formation was established through its overexpression in soybean, which increased the number of nodules relative to the wild-type. RNA interference had no effect on nodule number.
  - DRR1 is homologous with other dirigent proteins such as GmDRR2 and GmDRR3.
  - DRR1 promotes the synthesis of (+)-pinoresinol which is needed to increase lignin biosynthesis. Higher levels of lignin content and secondary cell wall deposition function as a physical barrier and inhibit the ability of Phytophthora sojae to infect soybeans.
  - The GmNAC1 transcription factor may bind to the DRR1 promoter to upregulate DRR1 expression and enhance Phytophthora sojae resistance.
phenotype_synopsis: GmDRR1 was induced in soybean roots by the presence of rhizobia and helped establish a symbiotic relationship that resulted in development of root nodules and nitrogen fixation. Additionally, DRR1 expression increased the resistance of soybean to Phytophthora sojae.
traits:
  - entity_name: nodulation
    entity: GO:0009877
  - entity_name: biological process involved in symbiotic interaction
    entity: GO:0044403
  - entity_name: microbial disease response
    entity: TO:0000112
  - entity_name: nitrogen fixation
    entity: GO:0009399
references:
  - citation: Shi, Zhang et al., 2020
    doi: 10.1094/MPMI-01-20-0017-R
    pmid: 32186464
  - citation: Yu, Zou et al., 2021
    doi: 10.1016/j.cj.2021.08.009
---
scientific_name: Glycine max
gene_symbols:
  - GmDRR2
gene_symbol_long: Disease Resistance Responsive 2
gene_model_pub_name: Glyma.11G150300
gene_model_full_id: glyma.Wm82.gnm2.ann1.Glyma.11G150300
confidence: 3
curators:
  - Marlene Dorneich-Hayes
  - Scott Kalberer
comments:
  - GmDRR1 and GmDRR2 are homologous dirigent proteins. The function of DRR1 may depend on dimer formation with DRR2.
phenotype_synopsis: GmDRR2 promoted a symbiotic relationship with rhizobia that resulted in development of root nodules and nitrogen fixation in soybeans.
traits:
  - entity_name: nodulation
    entity: GO:0009877
  - entity_name: biological process involved in symbiotic interaction
    entity: GO:0044403
  - entity_name: microbial disease response
    entity: TO:0000112
  - entity_name: nitrogen fixation
    entity: GO:0009399
references:
  - citation: Shi, Zhang et al., 2020
    doi: 10.1094/MPMI-01-20-0017-R
    pmid: 32186464
  - citation: Yu, Zou et al., 2021
    doi: 10.1016/j.cj.2021.08.009
    pmid: null