---
scientific_name: Glycine max
gene_symbols:
  - GmPHR1
gene_symbol_long: Phosphate Starvation Response 1
gene_model_pub_name: Glyma.01G009600
gene_model_full_id: glyma.Wm82.gnm2.ann1.Glyma.01G009600
confidence: 4
curators:
  - Marlene Dorneich-Hayes
  - Scott Kalberer
comments:
  - GmPHR1 is expressed throughout nodules and expression increases as nodules develop.
  - Transgenic overexpression increased nodule size and increased the concentration of N and P.
  - PHR1 and GmPHR4 promote each other's expression.
  - When phosphorus is abundant, overexpression of PHR1 represses GmPHT1-4.
  - PHR1 positively regulates GmPAP12 (see Wang, Yang et al., 2020).
phenotype_synopsis: GmPHR1 is a constitutively expressed transcription factor which induces expression of GmPHT1s to promote phosphate uptake. Together, PHRs and PHT1s maintain inorganic phosphate (Pi) homeostasis in nodules.
traits:
  - entity_name: regulation of biological process involved in symbiotic interaction
    entity: GO:0043903
  - entity_name: nodulation
    entity: GO:0009877
references:
  - citation: Lu, Cheng et al., 2020
    doi: 10.1104/pp.19.01209
    pmid: 32680974
  - citation: Isidra-Arellano, Pozas-Rodríguez et al., 2020
    doi: 10.1111/tpj.14789
    pmid: 32344464
  - citation: Wang, Yang et al., 2020
    doi: 10.3389/fpls.2020.00450
    pmid: 32499790
  - citation: Yang, Lan et al., 2022
    doi: 10.1111/jipb.13207
    pmid: 34962095
---
scientific_name: Glycine max
gene_symbols:
  - GmPHR4
gene_symbol_long: Phosphate Starvation Response 4
gene_model_pub_name: Glyma.02G108500
gene_model_full_id: glyma.Wm82.gnm2.ann1.Glyma.02G108500
confidence: 4
curators:
  - Marlene Dorneich-Hayes
  - Scott Kalberer
comments:
  - GmPHR4 is expressed in noninfected nodule tissues. Transgenic overexpression increased nodule size but decreased nodule number.
  - PHR4 targets GmPHT1-1, GmPHT1-4, and GmPHT1-11.
  - PHR4 and GmPHR1 promote each other's expression.
  - When phosphorus is abundant, overexpression of PHR4 increases expression of PHT1-4.
  - Silencing of PHR4 had no effect on PHT1-4 expression.
phenotype_synopsis: GmPHR4 is a constitutively expressed transcription factor which induces expression of GmPHT1s to promote phosphate uptake. Together, PHRs and PHT1s maintain inorganic phosphate (Pi) homeostasis in nodules.
traits:
  - entity_name: regulation of biological process involved in symbiotic interaction
    entity: GO:0043903
  - entity_name: nodulation
    entity: GO:0009877
references:
  - citation: Lu, Cheng et al., 2020
    doi: 10.1104/pp.19.01209
    pmid: 32680974
---
scientific_name: Glycine max
gene_symbols:
  - GmPHT1-1
gene_symbol_long: Phosphate Transporter 1-1
gene_model_pub_name: Glyma10G33030
gene_model_full_id: glyma.Wm82.gnm1.ann1.Glyma10G33030
confidence: 3
curators:
  - Marlene Dorneich-Hayes
  - Scott Kalberer
comments:
  - Expression is enhanced by GmPHR1 in N2-fixing regions.
  - Expression is enhanced in non N2-fixing regions by both PHR1 and GmPHR4.
  - Expression of GmPHT1-1 is positively correlated with nitrogen fixation.
phenotype_synopsis: GmPHT1-1 is a target of GmPHR1 and GmPHR4. It encodes a plasma membrane phosphate transporter.
traits:
  - entity_name: inorganic phosphate transmembrane transporter activity
    entity: GO:0005315
  - entity_name: regulation of biological process involved in symbiotic interaction
    entity: GO:0043903
  - entity_name: nodulation
    entity: GO:0009877
references:
  - citation: Lu, Cheng et al., 2020
    doi: 10.1104/pp.19.01209
    pmid: 32680974
  - citation: Yang, Lan et al., 2022
    doi: 10.1111/jipb.13207
    pmid: 34962095
---
scientific_name: Glycine max
gene_symbols:
  - GmPHT1-4
gene_symbol_long: Phosphate Transporter 1-4
gene_model_pub_name: Glyma.10G036800
gene_model_full_id: glyma.Wm82.gnm4.ann1.Glyma.10G036800
confidence: 3
curators:
  - Marlene Dorneich-Hayes
  - Scott Kalberer
comments:
  - GmPHR1 and GmPHR4 enhance expression of GmPHT1-4 in non N2-fixing regions.
  - When phosphorus concentration is low, PHR4 enhances PHT1-4 expression.
  - When phosphorus is readily available, overexpression of PHR1 represses PHT1-4.
  - Expression of GmPHT1-1 is positively correlated with nitrogen fixation.
phenotype_synopsis: GmPHT1-4 is a target of GmPHR1 and GmPHR4. It encodes a plasma membrane phosphate transporter.
traits:
  - entity_name: inorganic phosphate transmembrane transporter activity
    entity: GO:0005315
  - entity_name: regulation of biological process involved in symbiotic interaction
    entity: GO:0043903
  - entity_name: nodulation
    entity: GO:0009877
references:
  - citation: Lu, Cheng et al., 2020
    doi: 10.1104/pp.19.01209
    pmid: 32680974
  - citation: Yang, Lan et al., 2022
    doi: 10.1111/jipb.13207
    pmid: 34962095
---
scientific_name: Glycine max
gene_symbols:
  - GmPHT1-11
gene_symbol_long: Phosphate Transporter 1-11
gene_model_pub_name: Glyma.14G188000
gene_model_full_id: glyma.Wm82.gnm2.ann1.Glyma.14G188000
confidence: 4
curators:
  - Marlene Dorneich-Hayes
  - Scott Kalberer
comments:
  - GmPHT1-11 is expressed in noninfected nodule tissues.
  - RNAi silencing of PHT1-11 increased nodule number but decreased nodule size and nitrogenase activity.
  - Transgenic overexpression of PHT1-11 enhanced nitrogenase activity.
  - Expression of PHT1-11 is enhanced by GmPHR1, except in N2-fixing regions, where PHR1 represses PHT1-11.
  - PHT1-11 is repressed by GmPHR4.
  - Overexpression of PHT1-11 represses GmPHT1-4.
phenotype_synopsis: GmPHT1-11 is targeted by GmPHR1 and GmPHR4. It encodes a plasma membrane phosphate transporter.
traits:
  - entity_name: inorganic phosphate transmembrane transporter activity
    entity: GO:0005315
  - entity_name: regulation of biological process involved in symbiotic interaction
    entity: GO:0043903
  - entity_name: nodulation
    entity: GO:0009877
references:
  - citation: Lu, Cheng et al., 2020
    doi: 10.1104/pp.19.01209
    pmid: 32680974
  - citation: Yang, Lan et al., 2022
    doi: 10.1111/jipb.13207
    pmid: 34962095