---
scientific_name: Glycine max
gene_symbols:
  - GmTIR1A
gene_symbol_long: Transport Inhibitor Response 1A
gene_model_pub_name: Glyma.02G152800
gene_model_full_id: glyma.Wm82.gnm2.ann1.Glyma.02G152800
confidence: 5
curators:
  - Marlene Dorneich-Hayes
  - Scott Kalberer
comments:
  - TIR1A is strongly expressed in developing nodules, main and lateral roots, and especially in main root tips and lateral root primordia.
  - Expression in roots decreases as nodulation progresses.
  - TIR1A is upregulated by auxin.
phenotype_synopsis: TIR1A is an auxin receptor which positively regulates root growth and nodulation.
traits:
  - entity_name: auxin receptor activity
    entity: GO:0038198
  - entity_name: regulation of biological process involved in symbiotic interaction
    entity: GO:0043903
  - entity_name: nodulation
    entity: GO:0009877
  - relation_name: positively regulates
    relation: RO:0002213
  - entity_name: root development
    entity: GO:0048364
  - relation_name: positively regulates
    relation: RO:0002213
  - entity_name: positive regulation of lateral root development
    entity: GO:1901333
references:
  - citation: Cai, Wang et al., 2017
    doi: 10.1111/nph.14632
    pmid: 28598036
  - citation: Yang, Lan et al., 2022
    doi: 10.1111/jipb.13207
    pmid: 34962095
---
scientific_name: Glycine max
gene_symbols:
  - GmTIR1B
gene_symbol_long: Transport Inhibitor Response 1B
gene_model_pub_name: Glyma.10G021500
gene_model_full_id: glyma.Wm82.gnm2.ann1.Glyma.10G021500
confidence: 4
curators:
  - Marlene Dorneich-Hayes
  - Scott Kalberer
comments:
  - TIR1B is most strongly expressed in developing nodules and main and lateral roots.
  - Expression in roots decreases as nodulation progresses.
  - RNAi knockdowns of TIR1B have reduced nodulation.
phenotype_synopsis: TIR1B is an auxin receptor which positively regulates root growth and nodulation.
traits:
  - entity_name: auxin receptor activity
    entity: GO:0038198
  - entity_name: regulation of biological process involved in symbiotic interaction
    entity: GO:0043903
  - entity_name: nodulation
    entity: GO:0009877
  - relation_name: positively regulates
    relation: RO:0002213
  - entity_name: root development
    entity: GO:0048364
  - relation_name: positively regulates
    relation: RO:0002213
  - entity_name: positive regulation of lateral root development
    entity: GO:1901333
references:
  - citation: Cai, Wang et al., 2017
    doi: 10.1111/nph.14632
    pmid: 28598036
  - citation: Yang, Lan et al., 2022
    doi: 10.1111/jipb.13207
    pmid: 34962095
---
scientific_name: Glycine max
gene_symbols:
  - GmTIR1C
gene_symbol_long: Transport Inhibitor Response 1C
gene_model_pub_name: Glyma.19G206800
gene_model_full_id: glyma.Wm82.gnm2.ann1.Glyma.19G206800
confidence: 5
curators:
  - Marlene Dorneich-Hayes
  - Scott Kalberer
comments:
  - TIR1C is most strongly expressed in developing nodules and root meristems.
  - Expression in roots is upregulated by Bradyrhizobium japonicum and auxin but downregulated by miR393d.
phenotype_synopsis: TIR1C is an auxin receptor which positively regulates root growth and nodulation.
traits:
  - entity_name: auxin receptor activity
    entity: GO:0038198
  - entity_name: regulation of biological process involved in symbiotic interaction
    entity: GO:0043903
  - entity_name: nodulation
    entity: GO:0009877
  - relation_name: positively regulates
    relation: RO:0002213
  - entity_name: root development
    entity: GO:0048364
  - relation_name: positively regulates
    relation: RO:0002213
  - entity_name: regulation of root meristem growth
    entity: GO:0010082
  - relation_name: positively regulates
    relation: RO:0002213
references:
  - citation: Cai, Wang et al., 2017
    doi: 10.1111/nph.14632
    pmid: 28598036
  - citation: Yang, Lan et al., 2022
    doi: 10.1111/jipb.13207
    pmid: 34962095
---
scientific_name: Glycine max
gene_symbols:
  - GmTIR1D
gene_symbol_long: Transport Inhibitor Response 1D
gene_model_pub_name: Glyma.03G209400
gene_model_full_id: glyma.Wm82.gnm2.ann1.Glyma.03G209400
confidence: 4
curators:
  - Marlene Dorneich-Hayes
  - Scott Kalberer
comments:
  - TIR1D is most strongly expressed in developing nodules, main and lateral root tips, and lateral root primordia.
  - RNAi knockdowns of TIR1D have reduced nodulation.
phenotype_synopsis: TIR1D is an auxin receptor which positively regulates root growth and nodulation.
traits:
  - entity_name: auxin receptor activity
    entity: GO:0038198
  - entity_name: regulation of biological process involved in symbiotic interaction
    entity: GO:0043903
  - entity_name: nodulation
    entity: GO:0009877
  - relation_name: positively regulates
    relation: RO:0002213
  - entity_name: root development
    entity: GO:0048364
  - relation_name: positively regulates
    relation: RO:0002213
  - entity_name: positive regulation of lateral root development
    entity: GO:1901333
references:
  - citation: Cai, Wang et al., 2017
    doi: 10.1111/nph.14632
    pmid: 28598036
  - citation: Yang, Lan et al., 2022
    doi: 10.1111/jipb.13207
    pmid: 34962095
---
scientific_name: Glycine max
gene_symbols:
  - GmAFB3A
gene_symbol_long: Auxin-Signaling F-Box 3A
gene_model_pub_name: Glyma.19G100200
gene_model_full_id: glyma.Wm82.gnm2.ann1.Glyma.19G100200
confidence: 5
curators:
  - Marlene Dorneich-Hayes
  - Scott Kalberer
comments:
  - AFB3A is most strongly expressed in developing nodules, main and lateral roots, and especially in main root tips and lateral root primordia.
  - AFB3A is upregulated by the presence of auxin but downregulated by miR393d.
  - RNAi knockdowns of AFB3A have reduced nodulation.
  - Transgenic overexpression of AFB3A did not increase nodulation.
phenotype_synopsis: AFB3A is an auxin receptor which has a minor role in the positive regulation of root growth and nodulation.
traits:
  - entity_name: auxin receptor activity
    entity: GO:0038198
  - entity_name: regulation of biological process involved in symbiotic interaction
    entity: GO:0043903
  - entity_name: nodulation
    entity: GO:0009877
  - relation_name: positively regulates
    relation: RO:0002213
  - entity_name: root development
    entity: GO:0048364
  - relation_name: positively regulates
    relation: RO:0002213
  - entity_name: positive regulation of lateral root development
    entity: GO:1901333
references:
  - citation: Cai, Wang et al., 2017
    doi: 10.1111/nph.14632
    pmid: 28598036
  - citation: Yang, Lan et al., 2022
    doi: 10.1111/jipb.13207
    pmid: 34962095
---
scientific_name: Glycine max
gene_symbols:
  - GmAFB3B
gene_symbol_long: Auxin-Signaling F-Box 3B
gene_model_pub_name: Glyma.16G050500
gene_model_full_id: glyma.Wm82.gnm2.ann1.Glyma.16G050500
confidence: 4
curators:
  - Marlene Dorneich-Hayes
  - Scott Kalberer
comments:
  - Expression of AFB3B is barely detectable in roots and developing nodules.
  - It is likely involved in shoot development rather than in root growth and nodulation.
  - RNAi knockdowns of AFB3B have reduced nodulation.
phenotype_synopsis: AFB3B is an auxin receptor.
traits:
  - entity_name: auxin receptor activity
    entity: GO:0038198
  - relation_name: positively regulates
    relation: RO:0002213
  - entity_name: shoot system development
    entity: GO:0048367
references:
  - citation: Cai, Wang et al., 2017
    doi: 10.1111/nph.14632
    pmid: 28598036
  - citation: Yang, Lan et al., 2022
    doi: 10.1111/jipb.13207
    pmid: 34962095