##### PUB RECORD #####
## 10.1007/s11103-008-9314-8  18301989  Aubry, Mani et al., 2008  "Aubry S, Mani J, Hörtensteiner S. Stay-green protein, defective in Mendel's green cotyledon mutant, acts independent and upstream of pheophorbide a oxygenase in the chlorophyll catabolic pathway. Plant Mol Biol. 2008 Jun;67(3):243-56. doi: 10.1007/s11103-008-9314-8. PMID: 18301989." ##

PMID- 18301989
OWN - NLM
STAT- MEDLINE
DCOM- 20080819
LR  - 20240109
IS  - 0167-4412 (Print)
IS  - 0167-4412 (Linking)
VI  - 67
IP  - 3
DP  - 2008 Jun
TI  - Stay-green protein, defective in Mendel's green cotyledon mutant, acts 
      independent and upstream of pheophorbide a oxygenase in the chlorophyll catabolic 
      pathway.
PG  - 243-56
LID - 10.1007/s11103-008-9314-8 [doi]
AB  - Type C stay-green mutants are defined as being defective in the pathway of 
      chlorophyll breakdown, which involves pheophorbide a oxygenase (PAO), required 
      for loss of green color. By analyzing senescence parameters, such as protein 
      degradation, expression of senescence-associated genes and loss of photosynthetic 
      capacity, we demonstrate that JI2775, the green cotyledon (i) pea line used by 
      Gregor Mendel to establish the law of genetics, is a true type C stay-green 
      mutant. STAY-GREEN (SGR) had earlier been shown to map to the I locus. The defect 
      in JI2775 is due to both reduced expression of SGR and loss of SGR protein 
      function. Regulation of PAO through SGR had been proposed. By determining PAO 
      protein abundance and activity, we show that PAO is unaffected in JI2775. 
      Furthermore we show that pheophorbide a accumulation in the mutant is independent 
      of PAO. When silencing SGR expression in Arabidopsis pao1 mutant, both 
      pheophorbide a accumulation and cell death phenotype, typical features of pao1, 
      are lost. These results confirm that SGR function within the chlorophyll 
      catabolic pathway is independent and upstream of PAO.
FAU - Aubry, Sylvain
AU  - Aubry S
AD  - Institute of Plant Biology, University of Zurich, Zurich, Switzerland.
FAU - Mani, Jan
AU  - Mani J
FAU - Hortensteiner, Stefan
AU  - Hortensteiner S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Plant Mol Biol
JT  - Plant molecular biology
JID - 9106343
RN  - 0 (Chlorophyllides)
RN  - 0 (DNA Primers)
RN  - 0 (Plant Proteins)
RN  - 1406-65-1 (Chlorophyll)
RN  - 142M471B3J (Carbon Dioxide)
RN  - 14897-06-4 (chlorophyllide a)
RN  - EC 1.13.- (Oxygenases)
RN  - EC 1.13.- (pheide a oxygenase)
SB  - IM
MH  - Carbon Dioxide/metabolism
MH  - Cellular Senescence
MH  - Chlorophyll/*metabolism
MH  - Chlorophyllides/metabolism
MH  - Cloning, Molecular
MH  - Cotyledon/*enzymology/genetics
MH  - DNA Primers
MH  - Oxygenases/*genetics/*metabolism
MH  - Pisum sativum/*enzymology/*genetics
MH  - Plant Leaves/enzymology/physiology
MH  - Plant Proteins/genetics/metabolism
EDAT- 2008/02/28 09:00
MHDA- 2008/08/20 09:00
CRDT- 2008/02/28 09:00
PHST- 2007/10/18 00:00 [received]
PHST- 2008/02/12 00:00 [accepted]
PHST- 2008/02/28 09:00 [pubmed]
PHST- 2008/08/20 09:00 [medline]
PHST- 2008/02/28 09:00 [entrez]
AID - 10.1007/s11103-008-9314-8 [doi]
PST - ppublish
SO  - Plant Mol Biol. 2008 Jun;67(3):243-56. doi: 10.1007/s11103-008-9314-8.


##### PUB RECORD #####
## 10.1126/science.1132912  17204643  Armstead, Donnison et al., 2007  "Armstead I, Donnison I, Aubry S, Harper J, Hörtensteiner S, James C, Mani J, Moffet M, Ougham H, Roberts L, Thomas A, Weeden N, Thomas H, King I. Cross-species identification of Mendel's I locus. Science. 2007 Jan 5;315(5808):73. doi: 10.1126/science.1132912. PMID: 17204643." ##

PMID- 17204643
OWN - NLM
STAT- MEDLINE
DCOM- 20070116
LR  - 20240109
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 315
IP  - 5808
DP  - 2007 Jan 5
TI  - Cross-species identification of Mendel's I locus.
PG  - 73
AB  - A key gene involved in plant senescence, mutations of which partially disable 
      chlorophyll catabolism and confer stay-green leaf and cotyledon phenotypes, has 
      been identified in Pisum sativum, Arabidopsis thaliana, and Festuca pratensis by 
      using classical and molecular genetics and comparative genomics. A stay-green 
      locus in F. pratensis is syntenically equivalent to a similar stay-green locus on 
      rice chromosome 9. Functional testing in Arabidopsis of a homolog of the rice 
      candidate gene revealed (i) senescence-associated gene expression and (ii) a 
      stay-green phenotype after RNA interference silencing. Genetic mapping in pea 
      demonstrated cosegregation with the yellow/green cotyledon polymorphism (I/i) 
      first reported by Gregor Mendel in 1866.
FAU - Armstead, Ian
AU  - Armstead I
AD  - Institute of Grassland and Environmental Research, Aberystwyth SY23 3EB, UK. 
      ian.armstead@bbsrc.ac.uk
FAU - Donnison, Iain
AU  - Donnison I
FAU - Aubry, Sylvain
AU  - Aubry S
FAU - Harper, John
AU  - Harper J
FAU - Hortensteiner, Stefan
AU  - Hortensteiner S
FAU - James, Caron
AU  - James C
FAU - Mani, Jan
AU  - Mani J
FAU - Moffet, Matt
AU  - Moffet M
FAU - Ougham, Helen
AU  - Ougham H
FAU - Roberts, Luned
AU  - Roberts L
FAU - Thomas, Ann
AU  - Thomas A
FAU - Weeden, Norman
AU  - Weeden N
FAU - Thomas, Howard
AU  - Thomas H
FAU - King, Ian
AU  - King I
LA  - eng
GR  - BBS/E/G/00003001/BB_/Biotechnology and Biological Sciences Research 
      Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Arabidopsis Proteins)
RN  - 1406-65-1 (Chlorophyll)
SB  - IM
MH  - Amino Acid Sequence
MH  - Arabidopsis/*genetics/physiology
MH  - Arabidopsis Proteins/genetics
MH  - Chlorophyll/analysis/*metabolism
MH  - Chromosome Mapping
MH  - Cotyledon/physiology
MH  - Festuca/*genetics/physiology
MH  - Gene Expression Regulation, Plant
MH  - *Genes, Plant
MH  - Molecular Sequence Data
MH  - Pisum sativum/*genetics/physiology
MH  - Phenotype
MH  - Plant Leaves/physiology
MH  - RNA Interference
EDAT- 2007/01/06 09:00
MHDA- 2007/01/17 09:00
CRDT- 2007/01/06 09:00
PHST- 2007/01/06 09:00 [pubmed]
PHST- 2007/01/17 09:00 [medline]
PHST- 2007/01/06 09:00 [entrez]
AID - 315/5808/73 [pii]
AID - 10.1126/science.1132912 [doi]
PST - ppublish
SO  - Science. 2007 Jan 5;315(5808):73. doi: 10.1126/science.1132912.


##### PUB RECORD #####
## 10.1016/j.tplants.2009.01.002  19237309  Hortensteiner, 2009  "Hörtensteiner S. Stay-green regulates chlorophyll and chlorophyll-binding protein degradation during senescence. Trends Plant Sci. 2009 Mar;14(3):155-62. doi: 10.1016/j.tplants.2009.01.002. Epub 2009 Feb 23. PMID: 19237309." ##

PMID- 19237309
OWN - NLM
STAT- MEDLINE
DCOM- 20090729
LR  - 20240109
IS  - 1360-1385 (Print)
IS  - 1360-1385 (Linking)
VI  - 14
IP  - 3
DP  - 2009 Mar
TI  - Stay-green regulates chlorophyll and chlorophyll-binding protein degradation 
      during senescence.
PG  - 155-62
LID - 10.1016/j.tplants.2009.01.002 [doi]
AB  - Stay-green mutants are delayed in leaf senescence and have been identified from 
      different plant species, including many crops. Functional stay-greens have the 
      potential to increase plant productivity. In cosmetic stay-greens, however, 
      retention of chlorophyll during senescence is uncoupled from a decline of 
      photosynthetic capacity in these mutants. For many cosmetic stay-green mutants, 
      including Gregor Mendel's famous green cotyledon pea variety, molecular defects 
      were recently identified in orthologous stay-green genes. Stay-green genes encode 
      members of a new family of chloroplast-located proteins, which are likely to 
      function in dismantling of photosynthetic chlorophyll-apoprotein complexes. Their 
      activity is considered as a prerequisite for both chlorophyll and apoprotein 
      degradation during senescence.
FAU - Hortensteiner, Stefan
AU  - Hortensteiner S
AD  - Zurich-Basel Plant Science Center, Institute of Plant Biology, University of 
      Zurich, CH-8008 Zurich, Switzerland. shorten@botinst.uzh.ch
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090223
PL  - England
TA  - Trends Plant Sci
JT  - Trends in plant science
JID - 9890299
RN  - 0 (Light-Harvesting Protein Complexes)
RN  - 0 (Plant Proteins)
RN  - 1406-65-1 (Chlorophyll)
SB  - IM
MH  - Amino Acid Sequence
MH  - *Cellular Senescence
MH  - Chlorophyll/*metabolism
MH  - Light-Harvesting Protein Complexes/*metabolism
MH  - Molecular Sequence Data
MH  - Mutation/genetics
MH  - Plant Proteins/chemistry/genetics/*metabolism
MH  - *Protein Processing, Post-Translational
RF  - 80
EDAT- 2009/02/25 09:00
MHDA- 2009/07/30 09:00
CRDT- 2009/02/25 09:00
PHST- 2008/11/07 00:00 [received]
PHST- 2009/01/06 00:00 [revised]
PHST- 2009/01/08 00:00 [accepted]
PHST- 2009/02/25 09:00 [entrez]
PHST- 2009/02/25 09:00 [pubmed]
PHST- 2009/07/30 09:00 [medline]
AID - S1360-1385(09)00049-1 [pii]
AID - 10.1016/j.tplants.2009.01.002 [doi]
PST - ppublish
SO  - Trends Plant Sci. 2009 Mar;14(3):155-62. doi: 10.1016/j.tplants.2009.01.002. Epub 
      2009 Feb 23.


##### PUB RECORD #####
## 10.1073/pnas.0705521104  17709752  Sato, Morita et al., 2007  "Sato Y, Morita R, Nishimura M, Yamaguchi H, Kusaba M. Mendel's green cotyledon gene encodes a positive regulator of the chlorophyll-degrading pathway. Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14169-74. doi: 10.1073/pnas.0705521104. Epub 2007 Aug 20. PMID: 17709752; PMCID: PMC1955798." ##

PMID- 17709752
OWN - NLM
STAT- MEDLINE
DCOM- 20071017
LR  - 20240316
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 104
IP  - 35
DP  - 2007 Aug 28
TI  - Mendel's green cotyledon gene encodes a positive regulator of the 
      chlorophyll-degrading pathway.
PG  - 14169-74
AB  - Mutants that retain greenness of leaves during senescence are known as 
      "stay-green" mutants. The most famous stay-green mutant is Mendel's green 
      cotyledon pea, one of the mutants used in determining the law of genetics. Pea 
      plants homozygous for this recessive mutation (known as i at present) retain 
      greenness of the cotyledon during seed maturation and of leaves during 
      senescence. We found tight linkage between the I locus and stay-green gene 
      originally found in rice, SGR. Molecular analysis of three i alleles including 
      one with no SGR expression confirmed that the I gene encodes SGR in pea. 
      Functional analysis of sgr mutants in pea and rice further revealed that leaf 
      functionality is lowered despite a high chlorophyll a (Chl a) and chlorophyll b 
      (Chl b) content in the late stage of senescence, suggesting that SGR is primarily 
      involved in Chl degradation. Consistent with this observation, a wide range of 
      Chl-protein complexes, but not the ribulose-1,5-bisphosphate 
      carboxylase/oxygenase (Rubisco) large subunit, were shown to be more stable in 
      sgr than wild-type plants. The expression of OsCHL and NYC1, which encode the 
      first enzymes in the degrading pathways of Chl a and Chl b, respectively, was not 
      affected by sgr in rice. The results suggest that SGR might be involved in 
      activation of the Chl-degrading pathway during leaf senescence through 
      translational or posttranslational regulation of Chl-degrading enzymes.
FAU - Sato, Yutaka
AU  - Sato Y
AD  - Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 
      113-8657, Japan.
FAU - Morita, Ryouhei
AU  - Morita R
FAU - Nishimura, Minoru
AU  - Nishimura M
FAU - Yamaguchi, Hiroyasu
AU  - Yamaguchi H
FAU - Kusaba, Makoto
AU  - Kusaba M
LA  - eng
SI  - GENBANK/AAW82954
SI  - GENBANK/AAW82955
SI  - GENBANK/AAW82956
SI  - GENBANK/AAW82957
SI  - GENBANK/AAW82958
SI  - GENBANK/AAW82959
SI  - GENBANK/AAW82960
SI  - GENBANK/AAY98500
SI  - GENBANK/AB303331
SI  - GENBANK/AB303332
SI  - GENBANK/AK120554
SI  - GENBANK/AP008216
SI  - GENBANK/AY699948
SI  - GENBANK/AY850161
SI  - GENBANK/BAF49740
SI  - GENBANK/BAF49741
GR  - H23 IP001011/IP/NCIRD CDC HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070820
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 1406-65-1 (Chlorophyll)
SB  - IM
MH  - Chlorophyll/*metabolism
MH  - Cotyledon/*genetics
MH  - Gene Expression Regulation, Plant
MH  - Homeostasis
MH  - Membrane Potentials/physiology
MH  - Models, Genetic
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Pisum sativum/genetics
MH  - Photosynthesis
MH  - Plant Leaves/genetics
PMC - PMC1955798
COIS- The authors declare no conflict of interest.
EDAT- 2007/08/22 09:00
MHDA- 2007/10/18 09:00
PMCR- 2008/02/28
CRDT- 2007/08/22 09:00
PHST- 2007/08/22 09:00 [pubmed]
PHST- 2007/10/18 09:00 [medline]
PHST- 2007/08/22 09:00 [entrez]
PHST- 2008/02/28 00:00 [pmc-release]
AID - 0705521104 [pii]
AID - 7447 [pii]
AID - 10.1073/pnas.0705521104 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14169-74. doi: 
      10.1073/pnas.0705521104. Epub 2007 Aug 20.